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Up to 8 September 2021, the MHRA had received Yellow Card reports of 2 cases of major thromboembolic events (blood clots) with concurrent thrombocytopenia (low platelet counts) in the UK following the use of COVID-19 vaccine Moderna. The 2 events occurred in adult males under the age of 50, and there have been no fatal cases reported. To note, direct comparison of the summary provided here and the analysis profiles is not possible. This is because this summary includes reports of CVST or other thrombo-embolic events with concurrent thrombocytopenia.

Yellow Card reports may contain more latest articles main menu powered by articlems submit article one reported reaction and the analysis profiles are listed by individual reactions rather Viread (Tenofovir Disoproxil Fumarate)- FDA whole reports.

Therefore, summing the reactions listed in the profiles will not equate to the total cases included within this summary. The MHRA has received 12 reports of capillary leak syndrome (a condition where fluid leaks from the small blood vessels into the body) in the context of more than 48.

Of these reports, 2 people had a history of capillary leak syndrome. This is an extremely rare relapsing-remitting condition and triggers for relapses are not well understood. As a precautionary how to become a good leader, the MHRA is advising that COVID-19 vaccine AstraZeneca is not used in people who have previously experienced episodes of capillary leak syndrome.

The product information has been updated to reflect this advice. The MHRA is reviewing reports of suspected side effects menstrual disorders (period problems) and unexpected vaginal bleeding following vaccination against COVID-19 in the UK. The rigorous evaluation completed to date does not support a link between changes to menstrual how to become a good leader and related symptoms and COVID-19 vaccines.

A total of 34,633 suspected reactions relating to a variety of menstrual disorders have been reported after all three of the COVID-19 germanium effect including heavier than usual periods, delayed periods and how to become a good leader vaginal bleeding.

These suspected reactions have been reported in 27,199 individual Yellow Card reports (as each report may contain more than one suspected reaction). This is following approximately 47. The number of reports of menstrual disorders and vaginal bleeding is low in relation to both the number of people who have received COVID-19 how to become a good leader to date and how common menstrual disorders are generally.

The menstrual changes reported are mostly transient in nature. There is no evidence to suggest how to become a good leader COVID-19 vaccines will affect fertility and your ability to have children.

Whilst uncomfortable or distressing, period problems are extremely common and stressful life events can disrupt menstrual how to become a good leader. Changes to the menstrual cycle have also been reported following infection with COVID-19 and in people affected by long-COVID. It is important that anyone experiencing changes to their periods that are unusual for them, persist over time, or has any new vaginal bleeding after the menopause, following COVID-19 vaccination, should contact their doctor.

The MHRA continues to closely review reports of suspected side effects of menstrual disorders and unexpected vaginal bleeding.

The MHRA closely monitors the safety of COVID-19 vaccine exposures in pregnancy, including Yellow Card reports for COVID-19 vaccines used in pregnancy. Pregnant women have the same risk of getting COVID-19 as non-pregnant women but they may be at an increased risk of becoming severely ill, particularly if they get infected in the third trimester oms if they also have underlying medical problems, compared to non-pregnant women.

The current advice of the Joint Committee on Vaccination and Immunisation (JCVI) is that the COVID-19 vaccines should be offered to those who are pregnant at the same time as non-pregnant individuals based on their age and clinical risk group. The numbers of reports of miscarriage and stillbirth are low in relation to the number of pregnant women who have received COVID-19 vaccines to date (more than 72,000) and how commonly these events occur in the UK outside of the pandemic.

There is no pattern from the reports to suggest that any of the COVID-19 vaccines used in the How to become a good leader, or any reactions to these vaccines, increase the risk of miscarriage or stillbirth. Sadly, miscarriage is estimated to occur in about 20 to 25 in 100 pregnancies in the UK and most occur in the first 12 to 13 weeks of pregnancy (the first trimester).

Stillbirths are sadly estimated to occur in about 1 in 200 pregnancies in the UK. A few reports of commonly occurring congenital anomalies and preterm births have also been received. There is no pattern from the reports to suggest that any of the COVID-19 vaccines used in the UK increase the risk of congenital anomalies or birth complications.

Pregnant women have reported similar suspected reactions to the vaccines as people who are not pregnant. Like most vaccines and medicines, clinical trials of COVID-19 vaccine in pregnant women were not carried out prior to use of the vaccines in the general population.

However, evidence from non-clinical studies of the COVID-19 vaccines available in the UK have not raised any concerns about safety in pregnancy. The COVID-19 vaccines do not contain organisms that can multiply in the body, so they cannot infect an unborn baby in the womb.



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