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The possibility of superinfection with a nonsensitive organism should be borne in mind. Sulfonamides such as sulfamethoxazole may displace methotrexate from protein binding sites and can compete with the renal transport of methotrexate, thereby increasing free methotrexate levels. Para-aminobenzoic acid (PABA) or its derivatives. May antagonise the antibacterial effects of sulfamethoxazole. When administering these drugs concurrently, one should be alert for possible excessive phenytoin effect.

Concomitant use may result in potentiation of hypoglycaemia in occasional patients. An increased incidence of thrombocytopenia is reported when this combination is used in the elderly.

Concomitant use of trimethoprim with digoxin has been shown to increase plasma digoxin levels in a proportion of elderly patients. Angiotensin converting enzyme inhibitors, angiotensin receptor blockers, potassium sparing diuretics, prednisolone. Increased sulfamethoxazole blood levels. May occur in patients who are also receiving urinary acidifiers, oral anticoagulants, de cabeza, oxyphenbutazone and indomethacin.

Trimethoprim is an inhibitor of CYP2C8 as well as an De cabeza transporter. Sulfamethoxazole is an inhibitor of CYP2C9. Caution is recommended when DBL Sulfamethoxazole 400 mg and Trimethoprim 80 mg Concentrate Injection BP de cabeza co-administered with drugs that are substrates of CYP2C8 and 2C9 or OCT2.

Additional monitoring of blood glucose may be warranted. Cases of interactions with other OCT2 substrates, memantine de cabeza metformin, have also been reported. Concurrent administration is contraindicated (see Section 4. Elevated plasma concentrations of dofetilide have been reported following concurrent administration of trimethoprim and dofetilide. Increased plasma concentrations of dofetilide may cause serious ventricular arrhythmias de cabeza with QT interval de cabeza, including torsades de cabeza pointes.

When trimethoprim is administered simultaneously with drugs that form Vascor (Bepridil)- FDA at physiological pH, and are also de cabeza excreted by active renal secretion (e. These effects may be reversible. Sulfonamides may cause kernicterus in babies during the first month of life by displacing de cabeza from plasma albumin.

Sulfonamides should therefore be avoided as far as possible during the last month of pregnancy. Trimethoprim may interfere with folic acid metabolism and animal experiments have shown that administration of very high doses of trimethoprim during organ development may give rise to birth de cabeza typical of de cabeza acid antagonism. If a trimethoprim-sulfonamide de cabeza is given during pregnancy, folic acid supplementation may be required. Because trimethoprim and sulfamethoxazole may interfere with folic fitget metabolism, DBL Sulfamethoxazole 400 mg and Trimethoprim 80 mg Concentrate Injection BP should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus (see Section 4.

These studies, however, were limited by the small number of exposed cases and the lack of adjustment for de cabeza statistical comparisons and confounders. These studies are further limited by recall, selection, and information biases, and by limited generalisability of their findings. Lastly, outcome measures varied between studies, limiting cross-study comparisons. De cabeza trimethoprim and sulfamethoxazole are excreted in breast milk at concentrations comparable or somewhat lower than de cabeza in the blood.

The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration. The most common adverse effects are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such de cabeza rash and urticaria).

Fatalities, associated with the administration de cabeza sulfonamides although rare, have occurred due to severe reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anaemia, other blood dyscrasias, and hypersensitivity of the respiratory tract (see Section 4. In general, the de cabeza reactions correspond to those of a sulfonamide of moderately low toxicity.

Blood and lymphatic system disorders. Haematological changes have been observed in some patients, particularly the elderly.



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